On March 3, 1924, the first President of the Turkish Republic, Mustafa Kemal Atatürk, as part of his reforms, constitutionally abolished the institution of the Caliphate. Its powers within Turkey were transferred to the Grand National Assembly of Turkey (parliament) of the newly formed Turkish Republic and the title has since been inactive.

Scattered attempts to revive the Caliphate elsewhere in the Muslim world were made in the years immediately following its abandonment by Turkey, but none were successful. Hussein bin Ali, the Sharif of Mecca, the title of the former governors of the Hejaz, who aided the British during World War I and revolted against Istanbul, declared himself Caliph two days after Turkey relinquished the title. But his claim was largely ignored, and he was soon ousted and driven out of Arabia by Ibn Saud, a rival who had no interest in the Caliphate. The last Ottoman Sultan Mehmed VI made a similar attempt to re-establish himself as Caliph in the Hejaz after leaving Turkey, but he was also unsuccessful. A summit was convened at Cairo in 1926 to discuss the revival of the Caliphate, but most Muslim countries did not participate and no action was taken to implement the summit's resolutions.

Though the title Ameer al-Mumineen was adopted by the King of Morocco and Mullah Mohammed Omar, former head of the now-defunct Taliban regime of Afghanistan, neither claimed any legal standing or authority over Muslims outside the borders of their respective countries. The closest thing to a Caliphate in existence today is the Organisation of the Islamic Conference (OIC), an international organization with limited influence founded in 1969 consisting of the governments of most Muslim-majority countries.